Continuous Positive Airway Pressure (CPAP)
Continuios positive airway pressure is a method of Non-invasive ventilation.
Often shortened to CPAP, this modality maintains same positive pressure throughout whole respiratory cycle on inhalation and exhalation, which keeps the airways open and therefore assists in breathing.
Bi-Level Positive Airway Pressure (BiPAP)
Bi-Level positive airway pressure is a method of Non-invasive ventilation.
Shortened to BiPAP, this modality delivers inspiratory positive airway pressure (IPAP) to augment patients own spontaneous breath on inspiration and then on exhalation the machine returns to expiratory positive airway pressure (EPAP) which creates PEEP (Positive End Expiratory Pressure).
Vibrating Mesh Technology
How it works:
The aperture plate vibrates at 128,000 times a second. Each aperture plate has 1,000 precision formed holes, which act as a micro pump, drawing liquid and forming a low-velocity, fine-particle, nebulised mist
Aerogen Solo
Summary
Sources
† Study performed in healthy subjects.
‡ ‡Study performed in stable subjects with moderate-to-severe COPD.
§ Between-group difference in change from baseline to 120 minutes in patients with acute exacerbation of COPD.
- Pinto VL, Sharma S. Continuous Positive Airway Pressure. [Updated 2022 May 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482178/
- Davidson AC, Banham S, Elliott M, et al. BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults. Thorax. 2016;71 Suppl 2:ii1-ii35.
- 30-354 Rev U Aerogen Solo Instruction Manual
- Galindo-Filho VC, Ramos ME, Rattes CS, et al. Radioaerosol pulmonary deposition using mesh and jet nebulizers during noninvasive ventilation in healthy subjects. Respir Care. 2015;60(9):1238-1246.
- Galindo-Filho VC, Alcoforado L, Rattes C, et al. A mesh nebulizer is more effective than jet nebulizer to nebulize bronchodilators during non-invasive ventilation of subjects with COPD: A randomized controlled trial with radiolabeled aerosols. Respir Med. 2019;153:60-67.
- Avdeev S, Nuralieva G, Soe AK et al. Comparison of vibrating mesh and jet nebulizers during noninvasive ventilation in acute exacerbation of chronic obstructive pulmonary disease. J Aerosol Med Pulm Drug Deliv. 2021 Dec;34(6):358-365.
Abbreviations
- BIPAP - bi-level airway pressure
- COPD - chronic obstructive pulmonary disease
- CPAP - continuous positive airway pressure
- EPAP - expiratory positive airway pressure
- FEV1 - forced expiratory volume in 1 second
- FVC - forced vital capacity
- NIV - non-invasive ventilation
- IPAP - inspiratory positive airway pressure
- PEEP - positive end expiratory pressure
- RR - respiratory rate
- SpO2 - oxygen saturation
Aerogen Solo
Summary
The following statements summarise the information that has been covered in this learning module about Aerogen and Non-Invasive Ventilation.
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Aerogen supports improvements in patients' symptoms and bronchodilator response. In a study, aerosol drug delivery with Aerogen via NIV was associated with significant improvements in lung function (FEV1, FVC, breathlessness score, RR, and PaCO2) versus jet Nebulizers during acute exacerbations of COPD.§6
Aerogen Solo Summary
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